| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 22/02/25 20.30 | Inter Miami CF | New York City FC | -:- |
| 22/02/25 22.30 | Los Angeles FC | Minnesota United FC | -:- |
| 23/02/25 01.30 | Orlando City | Philadelphia Union | -:- |
| 23/02/25 01.30 | D.C. United | Toronto FC | -:- |
| 23/02/25 01.30 | Columbus Crew | Chicago Fire | -:- |
| 23/02/25 01.30 | Cincinnati FC | New York Red Bulls | -:- |
| 23/02/25 01.30 | Atlanta United FC | CF Montreal | -:- |
| 23/02/25 02.30 | St. Louis City SC | Colorado Rapids | -:- |
| 23/02/25 02.30 | Nashville SC | New England Revolution | -:- |
| 23/02/25 02.30 | Houston Dynamo | FC Dallas | -:- |
| 23/02/25 02.30 | Austin FC | Sporting Kansas City | -:- |
| 23/02/25 04.30 | Seattle Sounders | Charlotte FC | -:- |
| 23/02/25 04.30 | San Jose Earthquakes | Real Salt Lake | -:- |
| 23/02/25 22.00 | Portland Timbers | Vancouver Whitecaps | -:- |
| 24/02/25 01.00 | Los Angeles Galaxy | San Diego FC | -:- |