| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 22/03/25 19.30 | Cincinnati FC | Atlanta United FC | 2:2 |
| 22/03/25 21.30 | Minnesota United FC | Los Angeles Galaxy | 2:2 |
| 23/03/25 00.30 | Philadelphia Union | St. Louis City SC | 1:0 |
| 23/03/25 00.30 | New York Red Bulls | Toronto FC | 2:1 |
| 23/03/25 00.30 | Orlando City | D.C. United | 4:1 |
| 23/03/25 00.30 | Charlotte FC | San Jose Earthquakes | 4:1 |
| 23/03/25 00.30 | Columbus Crew | New York City FC | 0:0 |
| 23/03/25 01.30 | Sporting Kansas City | Los Angeles FC | 0:2 |
| 23/03/25 01.30 | Nashville SC | CF Montreal | 3:0 |
| 23/03/25 02.30 | Real Salt Lake | FC Dallas | 0:1 |
| 23/03/25 02.30 | Colorado Rapids | Portland Timbers | 0:3 |
| 23/03/25 03.30 | Vancouver Whitecaps | Chicago Fire | 1:3 |
| 23/03/25 03.30 | Seattle Sounders | Houston Dynamo | 0:0 |
| 23/03/25 21.00 | Austin FC | San Diego FC | 2:1 |